![]() ![]() ![]() This current review aimed to assess the influence of skin color variations in skin structure and functions as well as difference in dermatological disease patterns. However, the most significant ethnic skin color difference is determined by melanin content. Previous research has proposed that skin color variation is caused by a dynamic genetic mechanism, contributing to our understanding of how population demographic history and natural selection shape human genetic and phenotypic diversity. High quantities of melanin and melanogenic substances are typically accepted in darker skin to protect against UV radiation-induced molecular damage. Genetics determines constitutive skin color, which is reinforced by facultative melanogenesis and tanning reactions. The enzyme tyrosinase is primarily responsible for the genetic mechanism that controls human skin color. ![]() Summary: The quantity and quality of melanin are regulating by the expression of genes. Although the UV component of sunlight is known to cause skin damage, few researches have looked at the impact of non-UV solar radiation on skin physiology in terms of inflammation, and there is less information on the role of visible light in pigmentation. Ultraviolet (UV) is the most major modifiable risk factor for skin cancer and many other environmental-influenced skin disorders when it is abundant in the environment. The mechanisms through which the active vitamin D metabolite 1,25 dihydroxyvitamin D3 (or calcitriol) affects keratinocyte development are numerous and overlap with the mechanisms by which calcium influences keratinocyte differentiation. Vitamin D has recently been discovered to regulate cellular proliferation and differentiation in a variety of tissues, including the skin. Indeed, >150 genes have now been identified as having a direct or indirect effect on skin color. Melanin is produced by cells called melanocytes in the skin and is the primary determinant of skin color in people with darker skin. Many factors influence the color of people’s skin, but the pigment melanin is by far the most important. Human skin has a wide range of tones and colors, which can be seen in a wide range of demographic populations. Background: In the world scientific tradition, skin color is the primary physical characteristic used to divide humans into groups. ![]()
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